Pearl Jam and Kings of Leon also headlined. The Beastie Boys were originally set to headline instead of Kings of Leon, but they canceled their tour when MCA announced that he was being treated for cancer.

The rest of the day's lineup:
The Levon Helm Band, Ghostland Observatory, Mos Def, The Decemberists, Flogging Molly, Citizen Cope, Sound Tribe Sector 9, Bon Iver, Mute Math, !!!, ...And You Will Know Us by the Trail of Dead, Devotchka, The Scabs, Grizzly Bear, The Airborne Toxic Event, The Ravonettes, Frederico Aubele, The Felice Brothers, Eek-a-Mouse, Henry Butler, John Vanderslice, Zac Brown Band, The Virgins, Alberta Cross, Sam Roberts Band, Bell X1, Deer Tick, The Henry Clay People, Cotton Jones, Papa Mali, Jonathan Tyler & the Northern Lights, Mimicking Birds, Sarah Jaffe, The Soul Strippers, Jeffrey Steele, Damien Horne, River City Christianettes, Quinn Sullivan, The Dexateens, Mr. Leebot, Secret Agent 23 Skidoo, Ralph's World

Most of the show (except for Don't Drink the Water, Jimi Thing, Spaceman, Corn Bread, and Two Step) was included in the Larger Than Life...in 3D film, released in December 2009.